Anti-CHD4 Antibody (clone 4H4)

Mouse Anti Human Monoclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, E
Primary Accession	Q14839
Predicted	Human
Host	Mouse
Clonality	Monoclonal
Isotype	IgG2a,k
Clone Names	4H4
Calculated MW	218005 Da
Concentration (mg/ml)	0.38 mg/ml

Additional Information
Gene ID	1108
Alias Symbol	CHD4
Other Names	CHD4, ATP-dependent helicase CHD4, CHD-4, Mi-2b, Mi2-BETA
Reconstitution & Storage	Protein A purified
Precautions	Anti-CHD4 Antibody (clone 4H4) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	CHD4
Function	ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity).
Cellular Location	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes in interphase (By similarity). Localizes to sites of DNA damage in a manner dependent on ZMYND8 and ZNF687 (PubMed:27732854, PubMed:28977666). {ECO:0000250\|UniProtKB:Q6PDQ2, ECO:0000269\|PubMed:27732854, ECO:0000269\|PubMed:28977666}
Tissue Location	Widely expressed..