癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-RTCB / C22orf28 Antibody (aa201-214)
Goat Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y3I0 |
| Predicted | Human, Pig, Horse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 55210 Da |
| Concentration (mg/ml) | 0.5 mg/ml |
| Gene ID | 51493 |
|---|---|
| Alias Symbol | RTCB |
| Other Names | RTCB, Ankyrin repeat domain 54, C22orf28, DJ149A16.6, HSPC117, FAAP, RP1-149A16.6 |
| Target/Specificity | Human C22orf28. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-RTCB / C22orf28 Antibody (aa201-214) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RTCB (HGNC:26935) |
|---|---|
| Function | 3'-5' RNA ligase, catalytic subunit of the tRNA-splicing ligase complex (tRNA-LC), which is involved in the enzyme-dependent maturation of intron-containing pre-tRNAs. Functions downstream of the tRNA-splicing endonuclease that removes introns, ligating the two generated halves via phosphodiester bond formation (PubMed:40069351). The ligation reaction, which requires guanosine triphosphate (GTP) and Mn(2+), proceeds through three metal-dependent steps. The first step requires ZBTB8OS/Archease and involves the guanylylation of RTCB at its active site histidine, forming a covalent GMP-histidine intermediate. Before the second step, RTCB also hydrolyzes the 2',3'-cyclic phosphate (cP) at the 3' end of the 5' tRNA exon, typically generated by the tRNA-splicing endonuclease, producing a 3' phosphate. The covalently bound GMP is then transferred to this 3' phosphate to form an RNA(3')- P-P-(5')G intermediate. In the final step, the 5'-OH of the 3' exon attacks the activated 3' end of the 5' exon, forming a 3'-5' phosphodiester bond and releasing GMP (PubMed:24870230, PubMed:38493148). RTCB also functions in non-canonical, spliceosome- independent, cytoplasmic splicing of XBP1 mRNAs during the unfolded protein response (UPR). Upon endoplasmic reticulum (ER) stress, the endoribonuclease IRE1/ERN1 excises a short intron, generating free exon ends that are aligned by RNA-intrinsic, zipper-like stem-loop structures. These exon ends are then recognized and ligated by RTCB. This splicing event yields the active XBP1s transcription factor, which induces genes required to resolve protein folding defects in the endoplasmic reticulum (PubMed:25378478, PubMed:26483401, PubMed:38493148). |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000255|HAMAP- Rule:MF_03144, ECO:0000269|PubMed:24608264, ECO:0000269|PubMed:25378478}. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# ALS17883
Size:
50 µg
Price:
¥ 4,380.00
替代产品:
