癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-E4F1 / E4F Antibody (clone 4B10)
Mouse Anti Human Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q66K89 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a,k |
| Clone Names | 4B10 |
| Calculated MW | 83496 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 1877 |
|---|---|
| Alias Symbol | E4F1 |
| Other Names | E4F1, E4F, E4F transcription factor 1, p50E4F, Transcription factor E4F1, Transcription factor E4F, p120E4F, p120e4f transcription factor |
| Target/Specificity | Human E4F1 / E4F |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-E4F1 / E4F Antibody (clone 4B10) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | E4F1 |
|---|---|
| Synonyms | E4F |
| Function | May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. |
| Cellular Location | Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the cytoplasm. Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis. |
| Tissue Location | Ubiquitously expressed. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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