Anti-KCNIP2 / KCHIP2 Antibody (N-Terminus)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P
Primary Accession	Q9NS61
Predicted	Human
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Calculated MW	30907 Da
Concentration (mg/ml)	0.5 mg/ml

Additional Information
Gene ID	30819
Alias Symbol	KCNIP2
Other Names	KCNIP2, KCHIP2
Target/Specificity	Human KChIP2 protein. Predicted to react with mouse KChIP2 protein according to sequence homology.
Reconstitution & Storage	Immunoaffinity purified
Precautions	Anti-KCNIP2 / KCHIP2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	KCNIP2 (HGNC:15522)
Function	Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220). Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform- specific manner (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220). Involved in KCND2 and KCND3 trafficking to the cell surface (PubMed:12829703). May be required for the expression of I(To) currents in the heart (By similarity).
Cellular Location	[Isoform 1]: Cell membrane {ECO:0000250\|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250\|UniProtKB:Q9JM59}. Note=Detected on lipid rafts (By similarity). {ECO:0000250\|UniProtKB:Q9JM59} [Isoform 6]: Cell membrane {ECO:0000250\|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250\|UniProtKB:Q9JM59}
Tissue Location	Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart