癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-CCND2 / Cyclin D2 Antibody
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | P30279 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 33067 Da |
| Gene ID | 894 |
|---|---|
| Alias Symbol | CCND2 |
| Other Names | CCND2, KIAK0002, G1/S-specific cyclin D2, G1/S-specific cyclin-D2, Cyclin D2 |
| Target/Specificity | Human CCND2 / Cyclin D2 |
| Reconstitution & Storage | Affinity purified |
| Precautions | Anti-CCND2 / Cyclin D2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CCND2 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1583} |
|---|---|
| Function | Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:18827403, PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:18827403, PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:18827403, PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:18827403, PubMed:8114739). |
| Cellular Location | Nucleus. Cytoplasm. Nucleus membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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