癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PRDM12 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H4Q4 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 49AT1111.91.20 |
| Calculated MW | 40403 Da |
| Gene ID | 59335 |
|---|---|
| Other Names | PR domain zinc finger protein 12, 211-, PR domain-containing protein 12, PRDM12, PFM9 |
| Target/Specificity | This PRDM12 antibody was raised suing purified recombinant GST fusion protein encoding human PRDM12. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRDM12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRDM12 |
|---|---|
| Synonyms | PFM9 |
| Function | Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli. |
| Cellular Location | Nucleus. |
| Tissue Location | Not found in adult tissues except in dorsal root ganglia. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
SET domains and histone methylation. Xiao B, et al. Curr Opin Struct Biol, 2003 Dec. PMID 14675547.
A potential role for PRDM12 in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion. Reid AG, et al. Leukemia, 2004 Jan. PMID 14523459.
The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. Kontrogianni-Konstantopoulos A, et al. J Biol Chem, 2001 Jun 8. PMID 11274145.
The yin-yang of PR-domain family genes in tumorigenesis. Jiang GL, et al. Histol Histopathol, 2000 Jan. PMID 10668202.
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