PRDM12 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB |
---|---|
Primary Accession | Q9H4Q4 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | polyclonal |
Calculated MW | 40403 Da |
Gene ID | 59335 |
---|---|
Other Names | PR domain zinc finger protein 12, 211-, PR domain-containing protein 12, PRDM12, PFM9 |
Dilution | WB~~ 1:1000 |
Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
Storage Conditions | -20℃ |
Name | PRDM12 |
---|---|
Synonyms | PFM9 |
Function | Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli. |
Cellular Location | Nucleus. |
Tissue Location | Not found in adult tissues except in dorsal root ganglia. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May be involved in transcriptional regulation.
REFERENCES
Yang X.-H.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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Cat# AP50619