癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CD34 Antibody (Center)
Purified Mouse Monoclonal Antibody (Mab)
- 产品详情
- 文献引用 : 3
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-P-Leica, E |
|---|---|
| Primary Accession | P28906 |
| Other Accession | NP_001764 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1κ |
| Clone Names | 132CT29.1.5 |
| Calculated MW | 40716 Da |
| Antigen Region | 185-214 aa |
| Gene ID | 947 |
|---|---|
| Other Names | Hematopoietic progenitor cell antigen CD34, CD34, CD34 |
| Target/Specificity | This CD34 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 185-214 amino acids from the Central region of human CD34. |
| Dilution | IHC-P-Leica~~1:1000 IHC-P~~1:100~500 WB~~1:500~1000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD34 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD34 |
|---|---|
| Function | Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.
REFERENCES
Genome-wide association analysis identifies multiple loci related to resting heart rate. Eijgelsheim M, et al. Hum Mol Genet, 2010 Oct 1. PMID 20639392. The effect of CXCL12 processing on CD34+ cell migration in myeloproliferative neoplasms. Cho SY, et al. Cancer Res, 2010 Apr 15. PMID 20388788. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells. Stellos K, et al. Arterioscler Thromb Vasc Biol, 2010 Jun. PMID 20378847. Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3. Artico M, et al. Eur J Histochem, 2010 Mar 11. PMID 20353905.
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