癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
STC2 Antibody
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O76061 |
| Other Accession | NP_003705.1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgA,k |
| Clone Names | 339CT13.2.6 |
| Calculated MW | 33249 Da |
| Gene ID | 8614 |
|---|---|
| Other Names | Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2 |
| Target/Specificity | This STC2 monoclonal antibody is generated from mouse immunized with STC2 recombinant protein. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STC2 |
|---|---|
| Function | Has an anti-hypocalcemic action on calcium and phosphate homeostasis. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
REFERENCES
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Law, A.Y., et al. Exp. Cell Res. 316(3):466-476(2010)
Volland, S., et al. Int. J. Cancer 125(9):2049-2057(2009)
Ieta, K., et al. Int. J. Cancer 125(4):926-931(2009)
Tamura, K., et al. Cancer Sci. 100(5):914-919(2009)
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