癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IHH Antibody (C-term) (Ascites)
Mouse Monoclonal Antibody (Mab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q14623 |
| Other Accession | O75473, F1MT22, NP_034674.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG3 |
| Clone Names | 363CT4.1.6 |
| Calculated MW | 45251 Da |
| Gene ID | 3549 |
|---|---|
| Other Names | Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, IHH |
| Target/Specificity | This IHH Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human IHH. |
| Dilution | WB~~1:500~8000 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IHH Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IHH (HGNC:5956) |
|---|---|
| Function | Plays a role in embryonic morphogenesis; it is involved in the regulation of endochondral skeleton formation, and the development of retinal pigment epithelium (RPE), photoreceptors and periocular tissues (By similarity). |
| Cellular Location | [Indian hedgehog protein N-product]: Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The N-product remains associated with the cell surface. {ECO:0000250|UniProtKB:Q15465} |
| Tissue Location | Expressed in embryonic lung, and in adult kidney and liver |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
REFERENCES
van Dop, W.A., et al. Gastroenterology 139(5):1665-1676(2010) Koike, S., et al. Biochem. Biophys. Res. Commun. 400(1):66-71(2010) Rice, D.P., et al. Hum. Mol. Genet. 19(17):3457-3467(2010) Witte, F., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14211-14216(2010) Lyashenko, N., et al. Dev. Dyn. 239(8):2266-2277(2010)
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