癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ARSA Antibody (C-term) 精选
Mouse Monoclonal Antibody (Mab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P15289 |
| Other Accession | NP_000478.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine, Rabbit |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | 498CT24.1.2 |
| Calculated MW | 53588 Da |
| Antigen Region | 408-439 aa |
| Gene ID | 410 |
|---|---|
| Other Names | Arylsulfatase A, ASA, Cerebroside-sulfatase, Arylsulfatase A component B, Arylsulfatase A component C, ARSA |
| Target/Specificity | This ARSA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 408-439 amino acids from the C-terminal region of human ARSA. |
| Dilution | WB~~1:500~1000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARSA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ARSA (HGNC:713) |
|---|---|
| Function | Lysosomal enzyme that catalyzes the hydrolysis of cerebroside-3-sulfate (N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4- enine) into cerebroside and sulfate, a reaction that requires the activator protein saposin B (PubMed:10751093, PubMed:19224915, PubMed:24294900). Also involved in the catabolism of other sulfoglycosphingolipids such as SB1a and SM3 (beta-D-3-sulfogalactosyl- (1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) (By similarity). |
| Cellular Location | Endoplasmic reticulum. Lysosome |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.
REFERENCES
Cesani, M., et al. Hum. Mutat. 30 (10), E936-E945 (2009) : Matzner, U., et al. J. Biol. Chem. 284(14):9372-9381(2009) Bisgaard, A.M., et al. Clin. Genet. 75(2):175-179(2009) Lugowska, A., et al. Clin. Genet. 75(1):57-64(2009) Oshikawa, M., et al. Mol. Vis. 15, 482-494 (2009) :
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