癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PACSIN2 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UNF0 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,k |
| Clone Names | 1735CT116.76.60 |
| Calculated MW | 55739 Da |
| Gene ID | 11252 |
|---|---|
| Other Names | Protein kinase C and casein kinase substrate in neurons protein 2, Syndapin-2, Syndapin-II, PACSIN2 |
| Target/Specificity | This PACSIN2 antibody is generated from a mouse immunized with a recombinant protein between 250-486 amino acids from human PACSIN2. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PACSIN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PACSIN2 |
|---|---|
| Function | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9WVE8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9WVE8}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9WVE8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVE8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVE8}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9WVE8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVE8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVE8}. Early endosome {ECO:0000250|UniProtKB:Q9WVE8}. Recycling endosome membrane. Cell membrane {ECO:0000250|UniProtKB:Q9WVE8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVE8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVE8}. Cell projection. Membrane, caveola. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9WVE8}. Note=Detected at the neck of flask- shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1 {ECO:0000250|UniProtKB:Q9WVE8} |
| Tissue Location | Widely expressed. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
REFERENCES
Ritter B.,et al.FEBS Lett. 454:356-362(1999).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Modregger J.,et al.J. Cell Sci. 113:4511-4521(2000).
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
