癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ADAMTS4 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O75173 |
| Reactivity | Human |
| Predicted | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,κ |
| Clone Names | 1995CT113.89.78 |
| Calculated MW | 90197 Da |
| Gene ID | 9507 |
|---|---|
| Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, 3.4.24.82, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688 |
| Target/Specificity | This ADAMTS4 antibody is generated from a mouse immunized with a recombinant protein from the human region of human ADAMTS4. |
| Dilution | WB~~1:8000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADAMTS4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADAMTS4 |
|---|---|
| Synonyms | KIAA0688 |
| Function | Cleaves aggrecan, a cartilage proteoglycan, at the '392- Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
REFERENCES
Tortorella M.D.,et al.Science 284:1664-1666(1999).
Wainwright S.D.,et al.Matrix Biol. 25:317-320(2006).
Sawaji Y.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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