PNOC Antibody (Center)
Purified Mouse Monoclonal Antibody (Mab)
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Application ![]()
| WB, E |
---|---|
Primary Accession | Q13519 |
Reactivity | Human |
Predicted | Human |
Host | Mouse |
Clonality | monoclonal |
Isotype | IgG2b,κ |
Clone Names | 2133CT1268.37.7 |
Calculated MW | 20295 Da |
Gene ID | 5368 |
---|---|
Other Names | Prepronociceptin, Nocistatin, Nociceptin, Orphanin FQ, PPNOC, Orphanin FQ2, PNOC, OFQ |
Target/Specificity | This PNOC antibody is generated from a mouse immunized with a recombinant protein from human PNOC. |
Dilution | WB~~1:8000 E~~Use at an assay dependent concentration. |
Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PNOC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PNOC |
---|---|
Synonyms | OFQ |
Function | [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. |
Cellular Location | Secreted. |
Tissue Location | Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
REFERENCES
Mollereau C.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996).
Nothacker H.-P.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:8677-8682(1996).
Fiset M.E.,et al.Biochemistry 42:10498-10505(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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