PNOC Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IHC-P, E |
---|---|
Primary Accession | Q13519 |
Other Accession | Q62923, Q64387, O62647 |
Reactivity | Human, Rat, Mouse |
Predicted | Bovine, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 20295 Da |
Antigen Region | 126-151 aa |
Gene ID | 5368 |
---|---|
Other Names | Prepronociceptin, Neuropeptide 1, Nociceptin, Orphanin FQ, PPNOC, Neuropeptide 2, PNOC, OFQ |
Target/Specificity | This PNOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-151 amino acids from the Central region of human PNOC. |
Dilution | WB~~1:4000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PNOC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PNOC |
---|---|
Synonyms | OFQ |
Function | [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. |
Cellular Location | Secreted. |
Tissue Location | Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PNOC is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. This protein may be involved in neuronal differentiation and development
REFERENCES
Kuzmin,A., et.al., Brain Res. 1305 SUPPL, S80-S85 (2009)
Rocha,L., et.al., Neurobiol. Dis. 35 (3), 466-473 (2009)
de Krom,M., et.al., Biol. Psychiatry 65 (7), 625-630 (2009)

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