癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MUM1 Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q2TAK8 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4G10 |
| Isotype | IgG1 |
| Calculated MW | 78636 Da |
| Description | Mutated melanoma-associated antigen 1 (MUM1) is a 78 kDa protein encoded by the MUM1 gene. MUM1 is expressed in a subset of B cells in the light zone of the germinal center, plasma cells, activated T cells and a wide spectrum of related hematolymphoid neoplasms. Antibodies to MUM1 are useful in the sub classification of lymphoid malignancies. |
| Immunogen | Purified recombinant fragment of human MUM1 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 84939 |
|---|---|
| Other Names | PWWP domain-containing protein MUM1, Mutated melanoma-associated antigen 1, MUM-1, Protein expandere, MUM1, EXPAND1 |
| Dilution | WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000 E~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MUM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PWWP3A (HGNC:29641) |
|---|---|
| Function | Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. |
| Cellular Location | Nucleus. Note=Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1 |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1. Genome Res. 1996 Sep;6(9):791-806. 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903.
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