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PDE1B Antibody

Purified Mouse Monoclonal Antibody

     
  • 10 - PDE1B Antibody AO2280a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • 1 - PDE1B Antibody AO2280a
    Figure 1: Western blot analysis using PDE1B mAb against human PDE1B recombinant protein. (Expected MW is 44.4 kDa)
  • 1 - PDE1B Antibody AO2280a
    Figure 2: Western blot analysis using PDE1B mAb against HEK293 (1) and PDE1B (AA: 370-536)-hIgGFc transfected HEK293 (2) cell lysate.
  • 4 - PDE1B Antibody AO2280a
    Figure 3: Flow cytometric analysis of A549 cells using PDE1B mouse mAb (green) and negative control (red).
  • 2 - PDE1B Antibody AO2280a
    Figure 4: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using PDE1B mouse mAb with DAB staining.
  • 2 - PDE1B Antibody AO2280a
    Figure 5: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using PDE1B mouse mAb with DAB staining.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, FC, E
Primary Accession Q01064
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5C4A3
Isotype IgG1
Calculated MW 61380 Da
Description The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Immunogen Purified recombinant fragment of human PDE1B (AA: 370-536 ) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 5153
Other Names Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1B, Cam-PDE 1B, 3.1.4.17, 63 kDa Cam-PDE, PDE1B, PDE1B1, PDES1B
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
FC~~1/200 - 1/400
E~~1/10000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDE1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE1B (HGNC:8775)
Synonyms PDES1B
Function Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15260978, PubMed:8855339, PubMed:9419816). Has a preference for cGMP as a substrate (PubMed:9419816).
Cellular Location Cytoplasm, cytosol.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

1.J Biol Chem. 2007 Nov 9;282(45):32749-57. 2.Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):497-502.

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