GRM1
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application ![]()
| WB, IHC, ICC, E |
---|---|
Primary Accession | Q13255 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 5E12D8 |
Isotype | Mouse IgG1 |
Calculated MW | 132357 Da |
Immunogen | Purified recombinant fragment of human GRM1 (AA: extra 387-486) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Gene ID | 2911 |
---|---|
Other Names | MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85 |
Dilution | WB~~ 1/500 - 1/2000 IHC~~1:100~500 ICC~~N/A E~~ 1/10000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GRM1 is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GRM1 |
---|---|
Synonyms | GPRC1A, MGLUR1 |
Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively (PubMed:24357660, PubMed:27276689). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:P97772}. Note=Located in dendrioles, small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell {ECO:0000250|UniProtKB:P97772} |
Tissue Location | Detected in brain.. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1.Breast Cancer Res Treat. 2015 May;151(1):57-73.2.PLoS One. 2013 Jul 26;8(7):e69851.

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