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GRM1

Purified Mouse Monoclonal Antibody

     
  • 10 - GRM1 AO2613a
    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • 1 - GRM1 AO2613a
    Figure 2:Western blot analysis using GRM1 mAb against human GRM1 (AA: 387-486) recombinant protein. (Expected MW is 37.1 kDa)
  • 1 - GRM1 AO2613a
    Figure 3:Western blot analysis using GRM1 mAb against HEK293 (1) and GRM1 (AA: 387-486)-hIgGFc transfected HEK293 (2) cell lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, ICC, E
Primary Accession Q13255
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5E12D8
Isotype Mouse IgG1
Calculated MW 132357 Da
Immunogen Purified recombinant fragment of human GRM1 (AA: extra 387-486) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 2911
Other Names MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85
Dilution WB~~ 1/500 - 1/2000
IHC~~1:100~500
ICC~~N/A
E~~ 1/10000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGRM1 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRM1
Synonyms GPRC1A, MGLUR1
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively (PubMed:24357660, PubMed:27276689).
Cellular Location Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:P97772}. Note=Located in dendrioles, small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell {ECO:0000250|UniProtKB:P97772}
Tissue Location Detected in brain..
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

1.Breast Cancer Res Treat. 2015 May;151(1):57-73.2.PLoS One. 2013 Jul 26;8(7):e69851.

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