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CD183

Purified Mouse Monoclonal Antibody

     
  • 10 - CD183 AO2687a
    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • 1 - CD183 AO2687a
    Figure 2:Western blot analysis using CD183 mAb against human CD183 (AA: extra mix) recombinant protein. (Expected MW is 38.3 kDa)
  • 1 - CD183 AO2687a
    Figure 3:Western blot analysis using CD183 mAb against HEK293 (1) and CD183 (AA: extra mix)-hIgGFc transfected HEK293 (2) cell lysate.
  • 1 - CD183 AO2687a
    Figure 4:Western blot analysis using CD183 mouse mAb against Hela (1) and L-02 (2) cell lysate.
  • 51 - CD183 AO2687a
    Figure 5:Flow cytometric analysis of Jurkat cells using CD183 mouse mAb (green) and negative control (red).
  • 51 - CD183 AO2687a
    Figure 6:Flow cytometric analysis of Ramos cells using CD183 mouse mAb (green) and negative control (red).
  • 2 - CD183 AO2687a
    Figure 7:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CD183 mouse mAb with DAB staining.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, ICC, E
Primary Accession P49682
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5C10E6
Isotype Mouse IgG1
Calculated MW 40660 Da
Immunogen Purified recombinant fragment of human CD183 (AA: extra mix) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 2833
Other Names CXCR3; GPR9; MigR; CD182; Mig-R; CKR-L2; CMKAR3; IP10-R
Dilution WB~~ 1/500 - 1/2000
IHC~~1:100~500
ICC~~N/A
E~~ 1/10000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD183 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CXCR3
Synonyms GPR9
Function [Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G- protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. [Isoform 3]: Mediates the activity of CXCL11.
Cellular Location [Isoform 1]: Cell membrane; Multi-pass membrane protein
Tissue Location Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

1.Hum Pathol. 2015 Dec;46(12):1872-80. 2.Breast Cancer Res Treat. 2015 Jan;149(2):403-15.

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