癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NDUFAB1 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, IP |
|---|---|
| Primary Accession | O14561 |
| Other Accession | O14561 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 17417 Da |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from human NDUFAB1 |
| Epitope Specificity | 120-156 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| SIMILARITY | Contains 1 acyl carrier domain. |
| SUBUNIT | Mammalian complex I is composed of 45 different subunits. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Carrier of the growing fatty acid chain in fatty acid biosynthesis.Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). |
| Gene ID | 4706 |
|---|---|
| Other Names | ACP; ACP1; FASN2A; SDAP; 2210401F17Rik; 2310039H15Rik; 2610003B19Rik; 8kDa; 9130423F15Rik; CI-SDAP; ACPM_HUMAN; NDUFAB1; NADH-ubiquinone oxidoreductase 9.6 kDa subunit; ACPM_MOUSE; NADH:ubiquinone oxidoreductase subunit AB1; NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 (8kD, SDAP); NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa; acyl carrier protein, mitochondrial; complex I SDAP subunit |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IP=1:20-50,Flow-Cyt=1:50-100,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NDUFAB1 (HGNC:7694) |
|---|---|
| Function | Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) (PubMed:27626371). Accessory and non- catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:31664822). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN- dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). |
| Cellular Location | Mitochondrion |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,400.00
Cat# AP100055
