癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HOXD12 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P35452 |
| Other Accession | P35452 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 29031 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HOXD12 |
| Epitope Specificity | 171-270/270 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The Hox (homeobox) genes play an important role in the development and design of anterior-posterior body axes in animals. Although Hox proteins can bind to DNA as monomers, dimerization with PBX homeoproteins can significantly increase the DNA binding activity of these transcription factors. The HoxD9 gene is involved in the development and patterning of the forelimb and axial skeleton. Transcriptional activation of HoxD9 has been shown to be enhanced by HMG1 (high mobility group protein 1) and antagonized by HoxD8, suggesting that Hox protein function depends on both DNA-protein and protein-protein interactions. The HOX genes are known to regulate a number of cell adhesion molecules (CAMs), with HoxD9 specifically increasing levels of L-CAM transcripts. In presomitic mesoderm, HoxD1 displays dynamic stripes of expression. In the three stages of diencephalon development, HoxD1 is strongly expressed in the first two stages and downregulated in the third stage. |
| Gene ID | 3238 |
|---|---|
| Other Names | HOX4H; Hox-4.7; Hox-5.6; HXD12_HUMAN; HOXD12; Homeobox protein Hox-4H; HXD12_MOUSE; Homeobox protein Hox-4.7; Homeobox protein Hox-5.6; Hoxd-12; homeobox D12; homeo box D12 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HOXD12 |
|---|---|
| Synonyms | HOX4H |
| Function | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Cellular Location | Nucleus. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100173
