癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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Atp1a2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P50993 |
| Other Accession | P50993 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 112265 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Atp1a2 |
| Epitope Specificity | 851-950/1020 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. |
| DISEASE | Defects in ATP1A2 are the cause of migraine familial hemiplegic type 2 (FHM2) [MIM:602481]. FHM2 is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. Defects in ATP1A2 are a cause of alternating hemiplegia of childhood (AHC) [MIM:104290]. AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008] |
| Gene ID | 477 |
|---|---|
| Other Names | DEE98; FARIMPD; FHM2; MHP2; Atpa-3; mKIAA0778; RATATPA2; AT1A2_HUMAN; ATP1A2; Na(+)/K(+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2; 7.2.2.13; KIAA0778; AT1A2_MOUSE; Na(+)/K(+) ATPase alpha(+) subunit; AT1A2_RAT; ATPase Na+/K+ transporting subunit alpha 2; migraine, hemiplegic 2; ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; sodium/potassium-transporting ATPase subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ATP1A2 (HGNC:800) |
|---|---|
| Synonyms | KIAA0778 |
| Function | Catalytic subunit of the Na(+)/K(+)-ATPase that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle (PubMed:33880529). It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (PubMed:33880529). |
| Cellular Location | Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP100212
