癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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Prostatic acid phosphatase Mouse mAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P15309 |
| Other Accession | P15309 |
| Reactivity | Human |
| Predicted | Rat, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 44566 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Prostatic Acid Phosphatase |
| Isotype | IgG2b, Kappa |
| Purity | affinity purified by Protein A |
| Buffer | PBS containing 50% Glycerol, 0.5% BSA and 0.02% Proclin300. |
| SIMILARITY | Belongs to the histidine acid phosphatase family. |
| SUBUNIT | Homodimer; dimer formation is required for phosphatase activity. |
| Post-translational modifications | N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Prostatic Acid Phosphatase is Belongs to the histidine acid phosphatase family.Cellular localization;Secreted and Lysosome membrane. Predominantly localized in the plasma membrane but also detected in intracellular vesicles. |
| Gene ID | 55 |
|---|---|
| Other Names | ACPP; 5'-NT; ACP-3; TM-PAP; A030005E02Rik; FRAP; Lap; PAP; Ppal; Acpp11; RNACPP11; PPAP_BOVIN; ACP3; Protein tyrosine phosphatase ACP3; 3.1.3.2; PPAP_HUMAN; 5'-nucleotidase (5'-NT); Acid phosphatase 3; Ecto-5'-nucleotidase; Thiamine monophosphatase (TMPase); PPAP_MOUSE; Fluoride-resistant acid phosphatase (FRAP); PPAP_RAT; acid phosphatase, prostate; prostatic acid phosphatase |
| Dilution | IHC-P=1:100-500,IF=1:100-500,IHC-F=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ACP3 (HGNC:125) |
|---|---|
| Synonyms | ACPP |
| Function | A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:10506173, PubMed:15280042, PubMed:20498373, PubMed:9584846, PubMed:8132635). Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:10506173, PubMed:15280042). |
| Cellular Location | [Isoform 1]: Secreted |
| Tissue Location | Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Low expression in prostate carcinoma cells and tissues |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100270
