癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GNA15 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P30679 |
| Other Accession | Q9TU29, NP_002059.2 |
| Reactivity | Human, Mouse |
| Predicted | Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43508 Da |
| Antigen Region | 333-361 aa |
| Gene ID | 2769 |
|---|---|
| Other Names | Guanine nucleotide-binding protein subunit alpha-15, G alpha-15, G-protein subunit alpha-15, Epididymis tissue protein Li 17E, Guanine nucleotide-binding protein subunit alpha-16, G alpha-16, G-protein subunit alpha-16, GNA15, GNA16 |
| Target/Specificity | This GNA15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-361 amino acids from the C-terminal region of human GNA15. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GNA15 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNA15 |
|---|---|
| Synonyms | GNA16 |
| Function | Member of the G-protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling (PubMed:12748287, PubMed:20639119). Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses (PubMed:28421075). |
| Tissue Location | Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
REFERENCES
Smith, N.L., et al. Circ Cardiovasc Genet 3(3):256-266(2010)
Lee, M.M., et al. J. Leukoc. Biol. 86(6):1319-1329(2009)
Lo, R.K., et al. Cell. Signal. 20(11):2095-2106(2008)
Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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