癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IGSF1 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8N6C5 |
| Other Accession | Q925N6, Q7TQA1, NP_001164433.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 148936 Da |
| Antigen Region | 1270-1297 aa |
| Gene ID | 3547 |
|---|---|
| Other Names | Immunoglobulin superfamily member 1, IgSF1, Immunoglobulin-like domain-containing protein 1, Inhibin-binding protein, InhBP, Pituitary gland-specific factor 2, p120, IGSF1, IGDC1, KIAA0364, PGSF2 |
| Target/Specificity | This IGSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1270-1297 amino acids from the C-terminal region of human IGSF1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IGSF1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IGSF1 |
|---|---|
| Synonyms | IGDC1, KIAA0364, PGSF2 |
| Function | Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin- stimulated transcription. |
| Cellular Location | [Isoform 1]: Membrane; Multi-pass membrane protein [Isoform 3]: Secreted. |
| Tissue Location | Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine Expressed at very low levels in brain, thymus, ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Robakis, T., et al. J. Biol. Chem. 283(52):36369-36376(2008)
Nakayama, M., et al. Genome Res. 12(11):1773-1784(2002)
Tanaka, S., et al. J. Mol. Endocrinol. 28(1):33-44(2002)
Gui, Y., et al. J. Clin. Endocrinol. Metab. 86(5):2104-2110(2001)
Chapman, S.C., et al. Mol. Endocrinol. 15(4):668-679(2001)
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