癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CB086 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O95876 |
| Other Accession | NP_056994.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 85084 Da |
| Antigen Region | 676-705 aa |
| Gene ID | 51057 |
|---|---|
| Other Names | WD repeat-containing and planar cell polarity effector protein fritz homolog, hFRTZ, Bardet-Biedl syndrome 15 protein, WD repeat-containing and planar cell polarity effector protein, WDPCP, BBS15, C2orf86, FRITZ |
| Target/Specificity | This CB086 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 676-705 amino acids from the C-terminal region of human CB086. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CB086 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WDPCP |
|---|---|
| Synonyms | BBS15, C2orf86, FRITZ |
| Function | Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (PubMed:35427153). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q32NR9}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q32NR9} Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q32NR9} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The C2ORF86 gene encodes an ortholog of Drosophila 'fritz,' a cytoplasmic WD40 repeat protein that controls planar cell polarity (summarized by Kim et al., 2010 [PubMed 20671153]).
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, S.K., et al. Science 329(5997):1337-1340(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
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