癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CUZD1 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IF, WB, E |
|---|---|
| Primary Accession | Q86UP6 |
| Other Accession | NP_071317.2 |
| Reactivity | Human |
| Predicted | Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 68153 Da |
| Antigen Region | 579-607 aa |
| Gene ID | 50624 |
|---|---|
| Other Names | CUB and zona pellucida-like domain-containing protein 1, CUB and ZP domain-containing protein 1, Transmembrane protein UO-44, CUZD1 {ECO:0000312|EMBL:CAH700061} |
| Target/Specificity | This CUZD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 579-607 amino acids from the C-terminal region of human CUZD1. |
| Dilution | IHC-P~~1:100~500 IF~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CUZD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CUZD1 {ECO:0000312|EMBL:CAH70006.1} |
|---|---|
| Function | Localized to zymogen granules, where it functions in trypsinogen activation (By similarity). May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (PubMed:15184879). |
| Cellular Location | Zymogen granule membrane {ECO:0000250|UniProtKB:P70412}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P70412} |
| Tissue Location | Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.
REFERENCES
Leong, C.T., et al. Oncogene 26(6):870-880(2007) Blanchetot, C., et al. Methods 35(1):44-53(2005) Leong, C.T., et al. Oncogene 23(33):5707-5718(2004) Deloukas, P., et al. Nature 429(6990):375-381(2004) Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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