癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MFS10 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q14728 |
| Other Accession | NP_001111.3, NP_001139541.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48339 Da |
| Antigen Region | 245-274 aa |
| Gene ID | 10227 |
|---|---|
| Other Names | Major facilitator superfamily domain-containing protein 10, Tetracycline transporter-like protein, MFSD10, TETRAN |
| Target/Specificity | This MFS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the Central region of human MFS10. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MFS10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MFSD10 |
|---|---|
| Synonyms | TETRAN |
| Function | Probable organic anion transporter which may serve as a transporter for some non-steroidal anti-inflammatory drugs (NSAIDs) as well as other organic anions across the luminal membranes of renal proximal tubules at the final excretion step into the urine. |
| Cellular Location | Nucleus inner membrane {ECO:0000250|UniProtKB:Q9D2V8}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in luminal membrane of renal tubules (at protein level) (PubMed:18638446). Detected in all tissues tested with higher expression in heart, splee, kidney, leukocytes and prostate (PubMed:18638446). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq].
REFERENCES
Ushijima, H., et al. Biochem. Biophys. Res. Commun. 374(2):325-330(2008)
Mima, S., et al. FEBS Lett. 581(7):1457-1463(2007)
Duyao, M.P., et al. Hum. Mol. Genet. 2(6):673-676(1993)
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