癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SPB4 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P48594 |
| Other Accession | NP_002965.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44854 Da |
| Antigen Region | 268-296 aa |
| Gene ID | 6318 |
|---|---|
| Other Names | Serpin B4, Leupin, Peptidase inhibitor 11, PI-11, Squamous cell carcinoma antigen 2, SCCA-2, SERPINB4, PI11, SCCA2 |
| Target/Specificity | This SPB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-296 amino acids from the C-terminal region of human SPB4. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SPB4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SERPINB4 |
|---|---|
| Synonyms | PI11, SCCA2 |
| Function | May act as a protease inhibitor to modulate the host immune response against tumor cells. |
| Cellular Location | Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level |
| Tissue Location | Squamous cells. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SPB4 may act as a protease inhibitor to modulate the host immune response against tumor cells.
REFERENCES
Murakami, A., et al. Int. J. Oncol. 36(6):1395-1400(2010)
Higgins, W.J., et al. J. Biol. Chem. 285(6):3722-3729(2010)
Villano, G., et al. Int. J. Mol. Med. 25(1):137-143(2010)
Ahmed, S.T., et al. Biochem. Biophys. Res. Commun. 378(4):821-825(2009)
Yamane, Y., et al. Int. Arch. Allergy Immunol. 150(1):89-101(2009)
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