癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PCDH1 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q08174 |
| Other Accession | NP_115796.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 114743 Da |
| Antigen Region | 179-206 aa |
| Gene ID | 5097 |
|---|---|
| Other Names | Protocadherin-1, Cadherin-like protein 1, Protocadherin-42, PC42, PCDH1 |
| Target/Specificity | This PCDH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-206 amino acids from the N-terminal region of human PCDH1. |
| Dilution | WB~~1:500 IHC-P~~1:100~500 IF~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PCDH1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PCDH1 |
|---|---|
| Function | May be involved in cell-cell interaction processes and in cell adhesion. |
| Cellular Location | Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Found at cell- cell boundaries and probably at cell-matrix boundaries |
| Tissue Location | Highly expressed in the brain and neuro-glial cells |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.
REFERENCES
Koppelman, G.H., et al. Am. J. Respir. Crit. Care Med. 180(10):929-935(2009)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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