癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZEB2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| FC, WB, E |
|---|---|
| Primary Accession | O60315 |
| Other Accession | Q9R0G7, NP_055610.1, NP_001165124.1 |
| Reactivity | Human, Mouse |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 136447 Da |
| Antigen Region | 1078-1105 aa |
| Gene ID | 9839 |
|---|---|
| Other Names | Zinc finger E-box-binding homeobox 2, Smad-interacting protein 1, SMADIP1, Zinc finger homeobox protein 1b, ZEB2, KIAA0569, SIP1, ZFHX1B, ZFX1B |
| Target/Specificity | This ZEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1078-1105 amino acids from the C-terminal region of human ZEB2. |
| Dilution | FC~~1:10~50 WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZEB2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZEB2 (HGNC:14881) |
|---|---|
| Function | Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). |
| Cellular Location | Nucleus. Chromosome |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.
REFERENCES
Kumar, P.A., et al. J. Biol. Chem. 285(41):31148-31156(2010)
Li, A., et al. Cancer Res. 70(13):5226-5237(2010)
Ohashi, S., et al. Cancer Res. 70(10):4174-4184(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :
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