癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CALU Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O43852 |
| Other Accession | O35783, Q6XLQ7, O35887, Q3T0K1, NP_001124146.1, NP_001210.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rabbit, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37107 Da |
| Antigen Region | 217-246 aa |
| Gene ID | 813 |
|---|---|
| Other Names | Calumenin, Crocalbin, IEF SSP 9302, CALU |
| Target/Specificity | This CALU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human CALU. |
| Dilution | WB~~1:1000 IHC-P~~N/A E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CALU Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CALU |
|---|---|
| Function | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane. Golgi apparatus. Secreted. Melanosome. Sarcoplasmic reticulum lumen. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Location | Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Carlquist, J.F., et al. J. Thromb. Thrombolysis 30(3):358-364(2010)
Hernandez-Romero, D., et al. Ann. Med. 42(6):439-446(2010)
Harada, T., et al. Thromb. Res. 126(3):183-190(2010)
Voora, D., et al. Clin. Pharmacol. Ther. 87(4):445-451(2010)
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