癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC38A8 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | A6NNN8 |
| Other Accession | NP_001073911.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46731 Da |
| Antigen Region | 149-177 aa |
| Gene ID | 146167 |
|---|---|
| Other Names | Putative sodium-coupled neutral amino acid transporter 8, Solute carrier family 38 member 8, SLC38A8 |
| Target/Specificity | This SLC38A8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-177 amino acids from the Central region of human SLC38A8. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC38A8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC38A8 {ECO:0000250|UniProtKB:Q5HZH7, ECO:0000312|HGNC:HGNC:32434} |
|---|---|
| Function | Electrogenic sodium-dependent amino acid transporter with a preference for L-glutamine, L-alanine, L-histidine, L-aspartate and L- arginine. May facilitate glutamine uptake in both excitatory and inhibitory neurons. The transport mechanism and stoichiometry remain to be elucidated. |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q5HZH7}; Multi- pass membrane protein. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q5HZH7}. Cell projection, axon {ECO:0000250|UniProtKB:Q5HZH7} |
| Tissue Location | Expressed in fetal and adult brain, and spinal cord. In the brain, it is localized in the cell body and axon of the majority of neuronal cells and in a subset of glial cells. Found throughout the neuronal retina, with higher expression levels in the inner and outer plexiform layers and the photoreceptor layer. Very weak expression is also present in the kidneys, thymus, and testes |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SLC38A8 is a putative sodium-dependent amino acid/proton antiporter (By similarity).
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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