癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
WHSC1L1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q9BZ95 |
| Other Accession | NP_060248.2, NP_075447.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 161613 Da |
| Antigen Region | 188-217 aa |
| Gene ID | 54904 |
|---|---|
| Other Names | Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1, WHSC1L1, NSD3 |
| Target/Specificity | This WHSC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the N-terminal region of human WHSC1L1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | WHSC1L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NSD3 (HGNC:12767) |
|---|---|
| Synonyms | WHSC1L1 |
| Function | Histone methyltransferase. Preferentially dimethylates 'Lys- 4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. |
| Cellular Location | Nucleus. Chromosome. |
| Tissue Location | Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.
REFERENCES
Zhou, Z., et al. Biochem. Biophys. Res. Commun. 398(3):565-570(2010)
Kim, S.M., et al. Biochem. Biophys. Res. Commun. 345(1):318-323(2006)
Tonon, G., et al. Proc. Natl. Acad. Sci. U.S.A. 102(27):9625-9630(2005)
Rosati, R., et al. Blood 99(10):3857-3860(2002)
Stec, I., et al. Genomics 76 (1-3), 5-8 (2001) :
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