癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DDX3Y Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O15523 |
| Other Accession | NP_001116137.1, NP_004651.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 73154 Da |
| Antigen Region | 90-119 aa |
| Gene ID | 8653 |
|---|---|
| Other Names | ATP-dependent RNA helicase DDX3Y, DEAD box protein 3, Y-chromosomal, DDX3Y, DBY |
| Target/Specificity | This DDX3Y antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the N-terminal region of human DDX3Y. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DDX3Y Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DDX3Y |
|---|---|
| Function | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). |
| Cellular Location | Cytoplasm. Nucleus Note=Shuttles between the nucleus and the cytoplasm in an XPO1- dependent manner |
| Tissue Location | Widely expressed at the mRNA level, with highest levels in testis (PubMed:9381176). Testis-specific (at protein level) Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes (PubMed:15294876) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome. The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternatively spliced variants, encoding the same protein, have been identified.
REFERENCES
Rosinski, K.V., et al. Blood 111(9):4817-4826(2008)
Lardone, M.C., et al. Mol. Hum. Reprod. 13(10):705-712(2007)
Pope, S.N., et al. J. Steroid Biochem. Mol. Biol. 94 (1-3), 203-208 (2005) :
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Ficarro, S.B., et al. Rapid Commun. Mass Spectrom. 19(1):57-71(2005)
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