癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
P11 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P21128 |
| Other Accession | NP_001165910.1, NP_001165911.1, NP_006016.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46872 Da |
| Antigen Region | 2-32 aa |
| Gene ID | 8909 |
|---|---|
| Other Names | Poly(U)-specific endoribonuclease, 31--, Placental protein 11, PP11, Protein endoU, Uridylate-specific endoribonuclease, ENDOU |
| Target/Specificity | This P11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human P11. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | P11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ENDOU |
|---|---|
| Function | Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites (PubMed:18936097). Targets mRNAs to regulate their expression (PubMed:37803019). |
| Cellular Location | Secreted. |
| Tissue Location | Placental-specific, but also associated with various malignant neoplasms |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein.
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Laneve, P., et al. J. Biol. Chem. 283(50):34712-34719(2008)
Gioia, U., et al. J. Biol. Chem. 280(19):18996-19002(2005)
Jenne, D. Biochem. Biophys. Res. Commun. 176(3):1000-1006(1991)
Grundmann, U., et al. DNA Cell Biol. 9(4):243-250(1990)
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