癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CASS4 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NQ75 |
| Other Accession | NP_001157588.1, NP_001157587.1, NP_001157586.1, NP_065089.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87144 Da |
| Antigen Region | 610-639 aa |
| Gene ID | 57091 |
|---|---|
| Other Names | Cas scaffolding protein family member 4, HEF-like protein, HEF1-EFS-p130Cas-like protein, HEPL, CASS4, C20orf32, HEFL |
| Target/Specificity | This CASS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 610-639 amino acids from the C-terminal region of human CASS4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CASS4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CASS4 |
|---|---|
| Synonyms | C20orf32, HEFL |
| Function | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell junction, focal adhesion |
| Tissue Location | Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Possible docking protein which may play a role for tyrosine-kinase-based signaling related to cell adhesion. Regulates FAK activity, focal adhesion integrity, and cell spreading.
REFERENCES
Singh, M.K., et al. Mol. Biol. Cell 19(4):1627-1636(2008)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
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Cat# AP13515b
