癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
UBP46 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P62068 |
| Other Accession | P62069, A5WWB0, NP_001127695.1, NP_073743.2 |
| Reactivity | Human |
| Predicted | Zebrafish, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42442 Da |
| Antigen Region | 241-269 aa |
| Gene ID | 64854 |
|---|---|
| Other Names | Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46, USP46 |
| Target/Specificity | This UBP46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-269 amino acids from the C-terminal region of human UBP46. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UBP46 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | USP46 |
|---|---|
| Function | Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). |
| Cellular Location | Cytoplasm. Note=USP46/WDR48/WDR20 complex is predominantly cytoplasmic |
| Tissue Location | Broadly expressed.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).
REFERENCES
Kushima, I., et al. J. Hum. Genet. 55(3):133-136(2010)
Cohn, M.A., et al. J. Biol. Chem. 284(8):5343-5351(2009)
Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009)
Quesada, V., et al. Biochem. Biophys. Res. Commun. 314(1):54-62(2004)
Puente, X.S., et al. Nat. Rev. Genet. 4(7):544-558(2003)
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