癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PRSS8 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q16651 |
| Other Accession | NP_002764.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36431 Da |
| Antigen Region | 190-219 aa |
| Gene ID | 5652 |
|---|---|
| Other Names | Prostasin, 3421-, Channel-activating protease 1, CAP1, Serine protease 8, Prostasin light chain, Prostasin heavy chain, PRSS8 |
| Target/Specificity | This PRSS8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-219 amino acids from the Central region of human PRSS8. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRSS8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRSS8 |
|---|---|
| Function | Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). |
| Cellular Location | [Prostasin]: Cell membrane; Single-pass membrane protein [Prostasin heavy chain]: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus |
| Tissue Location | Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.
REFERENCES
Chen, Y.W., et al. J. Biol. Chem. 285(41):31755-31762(2010)
Chen, M., et al. Mol. Cell. Biochem. 337 (1-2), 259-266 (2010) :
Fu, Y.Y., et al. Hum. Reprod. 25(3):623-632(2010)
Ko, T., et al. J. Biomed. Biotechnol. 2010, 793843 (2010) :
Chang, J.H., et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 31(6):712-719(2009)
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