癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Plk5 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q4FZD7 |
| Other Accession | NP_898975.2 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 66055 Da |
| Antigen Region | 4-31 aa |
| Gene ID | 216166 |
|---|---|
| Other Names | Inactive serine/threonine-protein kinase PLK5, Polo-like kinase 5, PLK-5, Plk5 {ECO:0000250|UniProtKB:Q64702} |
| Target/Specificity | This Mouse Plk5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-31 amino acids from the N-terminal region of mouse Plk5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Plk5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Plk5 {ECO:0000250|UniProtKB:Q64702} |
|---|---|
| Function | Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation. |
| Cellular Location | Nucleus, nucleolus. Cytoplasm |
| Tissue Location | Expressed in the cerebellum, eye and brain cortex (at protein level). Expressed in highly differentiated tissues, such as brain, eyes and ovary. Not detectable in proliferating tissues, such as the colon, spleen and placenta |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PLK5 (Serine/threonine-protein kinase PLK5) belongs to the protein kinase superfamily and Ser/Thr protein kinase family and CDC5/Polo subfamily. PLK5P contains 1 POLO box domain and 1 Serine/Threonine protein kinase catalytic domain.
REFERENCES
Pereira, J.D., et al. Proc. Natl. Acad. Sci. U.S.A. 107(36):15957-15962(2010)
Andrysik, Z., et al. Nucleic Acids Res. 38(9):2931-2943(2010)
Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :
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