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为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HN1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, FC, E |
|---|---|
| Primary Accession | Q9UK76 |
| Other Accession | NP_001002033.1, NP_057269.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 16015 Da |
| Antigen Region | 58-86 aa |
| Gene ID | 51155 |
|---|---|
| Other Names | Hematological and neurological expressed 1 protein, Androgen-regulated protein 2, Hematological and neurological expressed 1 protein, N-terminally processed, HN1, ARM2 |
| Target/Specificity | This HN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human HN1. |
| Dilution | WB~~1:1000 IF~~1:10~50 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | JPT1 (HGNC:14569) |
|---|---|
| Function | Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
HN1 belongs to the HN1 family.
REFERENCES
Laughlin, K.M., et al. Pathol. Oncol. Res. 15(3):437-444(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Zougman, A., et al. J. Proteome Res. 5(4):925-934(2006)
Zhou, G., et al. Gene 331, 115-123 (2004) :
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