HN1 Antibody

Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, FC
Primary Accession	Q9UK76
Reactivity	Rat, Human, Mouse
Clonality	Monoclonal
Other Names	ARM2; HN1; HN1A;
Isotype	Rabbit IgG
Host	Rabbit
Calculated MW	16015 Da

Additional Information
Dilution	WB 1:500~1:2000 FC 1:50
Purification	Affinity-chromatography
Immunogen	A synthesized peptide derived from human HN1
Description	Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408).
Storage Condition and Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Protein Information
Name	JPT1 (HGNC:14569)
Function	Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408).
Cellular Location	Nucleus. Cytoplasm
Tissue Location	Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta