癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PAQR8 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8TEZ7 |
| Other Accession | NP_588608.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40464 Da |
| Antigen Region | 326-354 aa |
| Gene ID | 85315 |
|---|---|
| Other Names | Membrane progestin receptor beta, mPR beta, Lysosomal membrane protein in brain 1, Progestin and adipoQ receptor family member 8, Progestin and adipoQ receptor family member VIII, PAQR8, C6orf33, LMPB1, MPRB |
| Target/Specificity | This PAQR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-354 amino acids from the C-terminal region of human PAQR8. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PAQR8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAQR8 (HGNC:15708) |
|---|---|
| Function | Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Colocalizes with a lysosomal protein CTSD/cathepsin D. |
| Tissue Location | Highly expressed in the hypothalamus (PubMed:23161870). Also expressed in spinal cord, kidney and testis |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PAQR8 is steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity).
REFERENCES
Smith, J.L., et al. Steroids 73(11):1160-1173(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Tang, Y.T., et al. J. Mol. Evol. 61(3):372-380(2005)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Hammes, S.R. Proc. Natl. Acad. Sci. U.S.A. 100(5):2168-2170(2003)
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