癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
VPS45 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NRW7 |
| Other Accession | P97390, NP_009190.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 65077 Da |
| Antigen Region | 461-489 aa |
| Gene ID | 11311 |
|---|---|
| Other Names | Vacuolar protein sorting-associated protein 45, h-VPS45, hlVps45, VPS45, VPS45A, VPS45B |
| Target/Specificity | This VPS45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 461-489 amino acids from the C-terminal region of human VPS45. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VPS45 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | VPS45 |
|---|---|
| Synonyms | VPS45A, VPS45B |
| Function | May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. |
| Cellular Location | Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein Note=Associated with Golgi/endosomal vesicles and the trans-Golgi network. |
| Tissue Location | Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. [provided by RefSeq].
REFERENCES
Rahajeng, J., et al. Exp. Cell Res. 316(5):859-874(2010)
Kim, B.Y., et al. Biochem. Biophys. Res. Commun. 311(3):577-582(2003)
Dulubova, I., et al. EMBO J. 21(14):3620-3631(2002)
de Renzis, S., et al. Nat. Cell Biol. 4(2):124-133(2002)
Nielsen, E., et al. J. Cell Biol. 151(3):601-612(2000)
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