癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Erythropoietin Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P01588 |
| Other Accession | P07865, NP_000790.2 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21307 Da |
| Antigen Region | 28-48 aa |
| Gene ID | 2056 |
|---|---|
| Other Names | Erythropoietin, Epoetin, EPO |
| Target/Specificity | This Erythropoietin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-48 amino acids of human Erythropoietin. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Erythropoietin Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPO |
|---|---|
| Function | Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass (PubMed:28283061). Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3 (PubMed:9774108). |
| Cellular Location | Secreted. |
| Tissue Location | Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
EPO is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq].
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kristensen, P.L., et al. Eur. J. Endocrinol. 163(3):391-398(2010)
Kim, M.H., et al. Mol. Biol. (Mosk.) 44(4):656-663(2010)
Carraway, M.S., et al. Circ. Res. 106(11):1722-1730(2010)
Shi, Z., et al. Mol. Cancer Res. 8(4):615-626(2010)
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