癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GPKOW Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q92917 |
| Other Accession | NP_056513.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52229 Da |
| Antigen Region | 309-338 aa |
| Gene ID | 27238 |
|---|---|
| Other Names | G patch domain and KOW motifs-containing protein, G patch domain-containing protein 5, Protein MOS2 homolog, Protein T54, GPKOW, GPATC5, GPATCH5, T54 |
| Target/Specificity | This GPKOW antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-338 amino acids from the Central region of human GPKOW. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPKOW Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPKOW |
|---|---|
| Synonyms | GPATC5, GPATCH5, T54 |
| Function | RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12- type introns in pre-mRNAs (Probable). |
| Cellular Location | Nucleus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
T54, also known as GPKOW (G patch domain and KOW motifs), GPATC5 or GPATCH5 (G patch domain-containing protein 5), is a potential RNA-binding protein consisting of one central G patch domain and two C-terminal KOW domains. T54 is a 476 amino acid protein belonging to the MOS2 family. It is a mammalian homolog of the Arabidopsis thaliana MOS2 (modifier of SNC1, 2) nuclear protein that is required for innate immunity. Similar to A. thaliana MOS2, T54 localizes to the nucleus and contains G patch and KOW domains, suggesting that T54 may play a similar role in mammalian innate immunity.
REFERENCES
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Zhang, Y., et al. Curr. Biol. 15(21):1936-1942(2005)
Schindelhauer, D., et al. Genome Res. 6(11):1056-1069(1996)
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