癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FAIM2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BWQ8 |
| Other Accession | NP_036438.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35110 Da |
| Antigen Region | 76-105 aa |
| Gene ID | 23017 |
|---|---|
| Other Names | Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35, Transmembrane BAX inhibitor motif-containing protein 2, FAIM2, KIAA0950, LFG, LFG2, NMP35, TMBIM2 |
| Target/Specificity | This FAIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the Central region of human FAIM2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FAIM2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FAIM2 |
|---|---|
| Synonyms | KIAA0950, LFG, LFG2, NMP35, TMBIM2 |
| Function | Antiapoptotic protein which protects cells uniquely from Fas- induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Membrane raft Postsynaptic cell membrane |
| Tissue Location | Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FAIM2 protects cells uniquely from Fas-induced apoptosis.
REFERENCES
Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637(2010)
Bucan, V., et al. Cell. Mol. Biol. Lett. 15(2):296-310(2010)
Ng, M.C., et al. J. Clin. Endocrinol. Metab. 95(5):2418-2425(2010)
Li, S., et al. Am. J. Clin. Nutr. 91(1):184-190(2010)
Hotta, K., et al. J. Hum. Genet. 54(12):727-731(2009)
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