癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EPOR Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC, IF, E |
|---|---|
| Primary Accession | P19235 |
| Other Accession | NP_000112.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55065 Da |
| Antigen Region | 329-357 aa |
| Gene ID | 2057 |
|---|---|
| Other Names | Erythropoietin receptor, EPO-R, EPOR |
| Target/Specificity | This EPOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-357 amino acids from the Central region of human EPOR. |
| Dilution | WB~~1:1000 FC~~1:10~50 IF~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EPOR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPOR {ECO:0000303|PubMed:2163695, ECO:0000312|HGNC:HGNC:3416} |
|---|---|
| Function | Receptor for erythropoietin, which mediates erythropoietin- induced erythroblast proliferation and differentiation (PubMed:10388848, PubMed:2163695, PubMed:2163696, PubMed:8662939, PubMed:9774108). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3 (PubMed:11756159). May also activate the LYN tyrosine kinase (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P14753}; Single-pass type I membrane protein |
| Tissue Location | Erythroid cells and erythroid progenitor cells. [Isoform EPOR-S]: Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
REFERENCES
Lim, A.C., et al. Biochemistry 49(18):3797-3804(2010)
Perrotta, S., et al. PLoS ONE 5 (8), E12015 (2010) :
Khankin, E.V., et al. PLoS ONE 5 (2), E9246 (2010) :
Wincewicz, A., et al. Folia Histochem. Cytobiol. 47(3):425-430(2009)
Ketteler, R., et al. J. Biol. Chem. 278(4):2654-2660(2003)
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