癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CCNG2 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q16589 |
| Other Accession | NP_004345.1 |
| Reactivity | Human |
| Predicted | Rat, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38866 Da |
| Antigen Region | 215-243 aa |
| Gene ID | 901 |
|---|---|
| Other Names | Cyclin-G2, CCNG2 |
| Target/Specificity | This CCNG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the Central region of human CCNG2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCNG2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CCNG2 |
|---|---|
| Function | May play a role in growth regulation and in negative regulation of cell cycle progression. |
| Cellular Location | Cytoplasm. |
| Tissue Location | High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.
REFERENCES
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Choi, M.G., et al. J. Surg. Res. 157(2):168-174(2009)
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
Xu, G., et al. Mol. Biol. Cell 19(11):4968-4979(2008)
Kasukabe, T., et al. Cancer Sci. 99(8):1693-1698(2008)
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