癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PPIL1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y3C6 |
| Other Accession | Q9D0W5, Q5E992, NP_057143.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 18237 Da |
| Antigen Region | 63-91 aa |
| Gene ID | 51645 |
|---|---|
| Other Names | Peptidyl-prolyl cis-trans isomerase-like 1, PPIase, Rotamase PPIL1, PPIL1, CYPL1 |
| Target/Specificity | This PPIL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the Central region of human PPIL1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PPIL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPIL1 |
|---|---|
| Synonyms | CYPL1 |
| Function | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:33220177). PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (PubMed:33220177). Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177). |
| Cellular Location | Nucleus |
| Tissue Location | Ubiquitous, with the most abundant expression in heart and skeletal muscle |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
REFERENCES
Wang, X., et al. J. Biol. Chem. 285(7):4951-4963(2010)
Xu, C., et al. J. Biol. Chem. 281(23):15900-15908(2006)
Xu, C., et al. J. Biomol. NMR 31(2):179-180(2005)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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